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FROM:
Dennis Lensen, Erik C. Gelderblom, Dennis M. Vriezema, Philippe Marmottant, Nico Verdonschot, Michel Versluis, Nico de Jong and Jan C.M. van Hest (from 8 different institutions),
“Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release”, Soft Matter, Vo. 7, pp 5417-5422, 2011, DOI: 10.1039/C1SM05324H
ABSTRACT: A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.
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